Computational Biology Group Members
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Andrea Sottoriva
Oncology
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| Background |
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BSc in Computer Science from the University of Bologna, Italy in 2006. MSc in Mathematical Modelling from the University of Amsterdam, The Netherlands in 2008 with major in
coputational biology. Scientific programmer at the National Institute for Subatomic Physics (NIKHEF) within the astroparticle physics group from 2006 to 2008.
Currently I am a PhD student in Oncology at the University of Cambridge and I am located at the Cancer Research UK Cambridge Research Institute.
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| Research Overview |
My research focuses on developing mechanistic, multi-scale mathematical models of cancer formation and progression using an evolutionary approach. I then use the models I create and implement, together with
high-throughput sequencing data from patients or mouse xenografts (e.g. methylation patterns) to infer about the biology of the systems I simulate. In this last step I make use of Bayesian inference techniques, such as
Approximate Bayesian Computation, to explore the physical and biological properties of malignancies and to address open questions in cancer biology that are otherwise off-limits for wet labs.
In particular, I develop both Hybrid Cellular Automata (HCA) and Cellular Potts Models (CPM) to:
- Model tumor growth and invasion
- Model clonal expansion and phenotypical heterogeneity in tumors
- Model cancer stem cells
- Infer colon crypt dynamics
- Simulate crypt budding and fission
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