Computational Biology Group Members
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Leonard Goldstein (PhD Student)
Oncology
| Telephone: | +44 1223 40 4292 |
| Fax: | +44 1223 40 4208 |
| email: | ldg21at cam.ac.uk |
| Office Location: | Room 130G, CRUK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE |
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| | Background & Research Overview |
Leonard received a BA in Mathematics (2004) and an MPhil in Computational Biology (2005) from the University of Cambridge.
His research interests lie in the biology of small regulatory RNAs, such as microRNAs (miRNAs), endogenous small interfering RNAs and PIWI-interacting RNAs. His work is concerned with the statistical analysis of small RNA expression and related data (with a focus on bead-based flow-cytometric profiling and Illumina/Solexa sequencing). Past and ongoing research projects in collaboration with the Miska laboratory include the study of miRNA expression in human breast cancer and the characterization of distinct classes of small RNAs in the nematode C. elegans.
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| Selected Publications |
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- Das PP, Bagijn MP, Goldstein LD, Woolford JR, Lehrbach NJ, Sapetschnig A, Buhecha HR, Gilchrist MJ, Howe KL, Stark R, Matthews N, Berezikov E, Ketting RF, Tavaré S and Miska EA. "Piwi and piRNAs act upstream of an endogenous siRNA pathway to suppress Tc3 transposon mobility in the Caenorhabditis elegans germline". Molecular Cell 31, 79-90, July 11, 2008.
- Blenkiron C*, Goldstein LD*, Thorne NP, Spiteri I, Chin SF, Dunning MJ, Barbosa-Morais NL, Teschendorff AE, Green AR, Ellis IO, Tavaré S, Caldas C and Miska EA. "MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype". Genome Biology 2007, 8:R214.
* Equal contribution
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