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Breaking the waves: improved detection of copy number variation from microarray-based comparative genomic hybridization

John C. Marioni, Natalie P. Thorne, Armand Valsesia, Tomas Fitzgerald, Richard Redon, Heike Fiegler, T. Daniel Andrews, Barbara E. Stranger, Andrew G. Lynch, Emmanouil T. Dermitzakis, Nigel P. Carter, Simon Tavaré and Matthew E. Hurles


This page contains the R code needed to run the CNVmix algorithm that was described in the above paper.  A revised version of which was submitted to Genome Biology in June 2007.

CNVmix.R contains the R code necessary to run CNVmix. Before running this code, the snapCGH and mclust libraries will need to be installed.  Finally, the MA object containing the wave corrected log ratios and the Clone Information that are needed to apply CNVmix are available in the attached files.