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The ICGC project is utilising next generation sequencing technology to generate a comprehensive catalogue of genomic abnormalities in many tumour types.

Project overview

The International Cancer Genome Consortium (ICGC) is utilising next generation sequencing technology to generate a comprehensive catalogue of genomic abnormalities in many tumour types. As part of the ICGC effort to sequence the most common cancers, CRUK is supporting the sequencing of oesophageal adenocarcinoma in accordance with the ICGC guidelines.
The groups of Rebecca Fitzgerald and Simon Tavare, in collaboration with the OCCAMS network of health centres are collecting and performing whole genome sequencing on up to 500 selected cases with significant tumour cellularity (>70%). It is hoped that comprehensive analysis of large numbers of OAC patient samples will provide a step change in our understanding of OAC pathogenesis.

Project aims - Find out more about what we hope to achieve.